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design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

《医学前沿（英文）》 2019年 第13卷 第2期   页码 277-284 doi: 10.1007/s11684-018-0630-3

摘要： The development of new proton-pump inhibitors (PPIs) with less adverse effects by lowering the pKa values of nitrogen atoms in pyrimidine rings has been previously suggested by our group. In this work, we proposed that new PPIs should have the following features: (1) number of ring II= number of ring I+ 1; (2) preferably five, six, or seven-membered heteroatomic ring for stability; and (3) 1

关键词： proton-pump inhibitor     adverse effect     pharmacological mechanism     toxicological mechanism     pKa calculation    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

《医学前沿（英文）》 2021年 第15卷 第1期   页码 33-42 doi: 10.1007/s11684-019-0735-3

摘要： Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitors (ICIs) are the most successful agents approved for multiple advanced malignancies. However, given the nature of the non-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related adverse events (irAEs) in almost all organs or systems. Up to 90% of patients who received ICIs combination therapy experienced irAEs, of which majority were low-grade toxicity. Cytotoxic lymphocyte antigen-4 and programmed cell death protein-1/programmed cell death ligand 1 inhibitors usually display distinct features of irAEs. In this review, the mechanisms of action of ICIs and how they may cause irAEs are described. Some unsolved challenges, however really engrossing issues, such as the association between irAEs and cancer treatment response, tumor response to irAEs therapy, and ICIs in challenging populations, are comprehensively summarized.

关键词： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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逆压梯度下近壁湍流的喷射和扫掠

张强,陆利蓬

《中国工程科学》 2003年 第5卷 第11期   页码 47-50

摘要：

采用Fourier谱展开和紧致有限差分格式，选用两组共振三波为相干结构的初值，计算了其在零压和逆压梯度作用下的演化。对演化后期流场的2，4象限的运动进行了详细的分析。结果发现，在逆压梯度下，扫掠对雷诺应力的贡献要强于喷射。无论是在零压梯度还是逆压梯度下，uv和u2在法向的输运主要是靠Q2和Q4这两种运动来完成的。零压梯度下喷射部分对输运的贡献大于扫掠的部分。而在逆压梯度下喷射部分对输运的贡献明显减少，扫掠的作用要强于喷射。

关键词： 相干结构     湍流边界层     逆压梯度     直接数值模拟    

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surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverse

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 189-195 doi: 10.1007/s11684-017-0533-8

摘要：

Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post anesthesia care unit (PACU). Results indicated that only 11.4% of the patients were considered at a high risk of OSAS. Age and body mass index are the key factors for the risk of OSAS prevalence in China and also gender specific. Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with high risk of OSAS than others (6.8% vs. 0.9%, <0.001). They also stayed longer than others in the PACU (95±28 min vs. 62±19 min, <0.001). Age, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory events in the PACU. The BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are at high risk of OSAS and determine the potential risk of developing postoperative respiratory complications in the PACU.

关键词： obstructive sleep apnea     Berlin Questionnaire     Chinese surgical patients     adverse respiratory event    

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浅谈五种宫内节育器不良反应分析

李华洁

《中国工程科学》 2015年 第17卷 第6期   页码 28-30

摘要：

通过观察放置宫内节育器（IUD），爱母环（MCU）、母体乐（MCU375）、宫形环（GCU300）、TCU220C和吉妮环术后不良反应情况，为育龄妇女知情选择IUD提供参考依据。将671例自愿采取放置宫内节育器避孕而无禁忌症的妇女随机分成五组，分别放置A组MCU，B组MCU375，C组GCU300，D组TCU220C，E组吉妮环五种IDU，随访两年，对其术后月经量增多，经期延长，阴道不规则流血，疼痛，脱环，带器妊娠，白带增多情况进行比较。MCU的不良反应较为严重，MCU375和GCU300的不良反应次之，TCU220C和吉妮环不良反应最轻。GCU300的脱环率最高，TCU220C、MCU和MCU375、吉妮环的脱环率都比较低；带器妊娠MCU和GCU300最高，MCU375、TCU220C和吉妮环均低。临床应根据受器者的具体情况选择适当的IUD，提高育龄妇女对避孕措施的满意程度。

关键词： 节育环；不良反应；吉妮环    

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基于矿物异常分析的隧道内不良地质识别方法及案例分析 Article

许振浩, 余腾飞, 林鹏, 李术才

《工程（英文）》 2023年 第27卷 第8期   页码 150-160 doi: 10.1016/j.eng.2022.09.013

摘要： 本研究提出了一种基于矿物异常分析的隧道不良地质识别方法（adverse geology identification through mineral anomaly analysis, AGIMAA），

关键词： 矿物异常     不良地质     断层     蚀变     异常阈值    

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Multi-target combinatory strategy to overcome tumor immune escape

《医学前沿（英文）》 2022年 第16卷 第2期   页码 208-215 doi: 10.1007/s11684-022-0922-5

摘要： Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancer treatment. Many immune checkpoints were identified in the last decade since ipilimumab, which is the first immune checkpoint inhibitor to cytotoxic T-lymphocyte associated protein 4, had been approved by the US Food and Drug Administration (FDA) for the treatment of unresectable or metastatic melanoma in 2011. The use of several antibody drugs that target PD1/PD-L1 for various cancer treatments has been approved by the FDA. However, fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers. Approximately 80% of patients do not respond appropriately because of primary or acquired therapeutic resistance. Along with the characterization of more immune checkpoints, the combinatory treatment of multi-immune checkpoint inhibitors becomes a new option when monotherapy could not receive a good response. In this work, the author focuses on the combination therapy of multiple immune checkpoints (does not include targeted therapy of oncogenes or chemotherapy), introduces the current progression of multiple immune checkpoints and their related inhibitors, and discusses the advantages of combination therapy, as well as the risk of immune-related adverse events.

关键词： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

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Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

null

《医学前沿（英文）》 2017年 第11卷 第1期   页码 20-31 doi: 10.1007/s11684-016-0493-4

摘要：

To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before the results of imaging techniques are obtained. While traditional serum assays have limited sensitivity and specificity, gastrointestinal juice may provide relevant specific biomarkers because of its close contact with the tumor. Herein, the current progress in the relationship between gastrointestinal fluid analyses and GC is systematically and comprehensively reviewed. The detection of gastric juice pH, fluorescence spectrum, cytology, Helicobacter pylori-associated markers, nitrosamines, conventional tumor markers, amino acids, proteomics, microRNAs, long noncoding RNAs, protein-coding genes, vitamin C, etc., and combination tests of different category markers could provide important diagnostic and prognostic clues for gastrointestinal diseases. Particularly, early GC may be efficiently screened using gastric juice. Gastrointestinal fluid examination could also predict the adverse effects of postgastrectomy, such as pancreatic leakage, fistula, and abscess. Gastric fluid markers should be further studied to reveal the early predicators of malignancy and complications. The methods for obtaining the samples of gastrointestinal juice with minimum incision should also be comprehensively investigated.

关键词： gastrointestinal fluid     gastric carcinoma     biomarker     diagnosis     prognosis     gastrectomy     adverse events    

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TBM施工隧洞不良地质超前预报实践——以吉林省中部城市引松供水工程为例 Article

李术才, 聂利超, 刘斌

《工程（英文）》 2018年 第4卷 第1期   页码 131-137 doi: 10.1016/j.eng.2017.12.010

摘要：
由于隧洞掘进机（TBM）施工具有快速、安全、高效的显著优势, 采用TBM 施工的隧洞越来越多。然而，TBM 施工对地层的适应性较差，在施工过程中遭遇的诸如溶洞、断层或破碎带等不良地质，往往会造成突水突泥、塌方、卡机等灾害，严重危及施工安全。因此，提前探明掌子面前方的不良地质体及其含水情况极为重要。针对TBM 施工隧洞的复杂环境，本文以吉林引松供水工程TBM 施工隧洞为依托，综合运用地质分析、三维激发极化与地震超前地质预报方法，提出了适用于TBM 隧洞施工期的综合超前地质预报技术体系，对TBM 施工隧洞掌子面前方的溶洞、断层破碎带等不良地质进行了准确的预报。避免了隧洞突水突泥、塌方、卡机灾害的发生，对于TBM施工隧洞不良地质超前预报与TBM 安全高效掘进具有一定借鉴意义。

关键词： TBM 隧洞     综合超前预报     地质分析     三维激发极化法     地震法     不良地质体    

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Analysis of effect of different construction methods of piles on the end effect on skin friction of piles

ZHOU Hongbo, CHEN Zhuchang

《结构与土木工程前沿（英文）》 2007年 第1卷 第4期   页码 458-463 doi: 10.1007/s11709-007-0062-7

摘要： Based on the comparative analysis of end effect on skin friction of displacement-pile (driven pile), the end effect on skin friction of bored pile is studied. The end effect on skin friction between driven pile and bored pile is different and the end effect on skin friction of bored pile is reduce of skin friction in the soil layer adjacent to the pile end. The degradation degree of skin friction is deduced with the increase of the distance from pile end. The concept of additional mud cake formed by the effect of cushion at the bottom of borehole during pouring concrete is introduced to explain the mechanism of end effect on skin friction of the bored pile. The test results of post-grouting piles indicate that the post-grouting technique is an effective way to improve the end effect on skin friction of bored pile.

关键词： distance     different     concept     additional     bottom    

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A review on different theoretical models of electrocaloric effect for refrigeration

《能源前沿（英文）》 2023年 第17卷 第4期   页码 478-503 doi: 10.1007/s11708-023-0884-6

摘要： The performance parameters for characterizing the electrocaloric effect are isothermal entropy change and the adiabatic temperature change, respectively. This paper reviews the electrocaloric effect of ferroelectric materials based on different theoretical models. First, it provides four different calculation scales (the first-principle-based effective Hamiltonian, the Landau-Devonshire thermodynamic theory, phase-field simulation, and finite element analysis) to explain the basic theory of calculating the electrocaloric effect. Then, it comprehensively reviews the recent progress of these methods in regulating the electrocaloric effect and the generation mechanism of the electrocaloric effect. Finally, it summarizes and anticipates the exploration of more novel electrocaloric materials based on the framework constructed by the different computational methods.

关键词： electrocaloric effect     effective Hamiltonian     phase-field modeling     different theoretical models    

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A new miniaturized engine based on thermomagnetic effect of magnetic fluids

Lujun ZHOU, Yimin XUAN, Qiang LI, Wenlei LIAN

《能源前沿（英文）》 2009年 第3卷 第2期   页码 160-166 doi: 10.1007/s11708-009-0018-9

摘要： A new engine system, essentially consisting of a permanent NdFeB magnet, a kerosene-based magnetic fluid and a rotor, is proposed based on the thermomagnetic effect of a temperature-sensitive magnetic fluid. The rotor was driven by the thermal convection of the magnetic fluid in the presence of a homogeneous external magnetic field. A digital camera was used to record the rotation speed of the rotor to investigate the performance of the engine system under varying conditions such as heat load, heat sink temperature, and magnetic field distribution. The peak angle velocity obtained for the rotor was about 2.1 rad/min. The results illustrate that the rotation speed of the rotor increases as the input heat load increases, or as the heat sink temperature decreases. The performance of the motor is considerably influenced by the magnetic field imposed. Therefore, the performance of such an engine can be controlled conveniently by changing the external magnetic field and/or the temperature distribution in the fluid.

关键词： magnetic fluid     thermomagnetic effect     engine    

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244对有不良孕产史夫妇初次染色体断裂率检测结果分析

余宏亮,常明秀,曹恒海,薄立伟,王艳丽,吴艳红

《中国工程科学》 2014年 第16卷 第5期   页码 67-69

摘要：

为了了解有不良孕产史夫妇的染色体断裂率的发生情况，笔者对来河南省人口和计划生育科学技术研究院就诊的有不良孕产史夫妇的染色体断裂率分析的检查结果进行统计学分析。分析结果显示：男性患者的就诊年龄平均为29.07 岁，女性患者的就诊年龄平均为28.15 岁，年龄与染色体检测结果间无相关。男性患者中未发现断裂的占男性总数的32.38 %，女性患者中未发现染色体断裂的占女性总数的37.7 %；男性染色体断裂率为1 的占男性总数的38.11 %，女性染色体断裂率为1 的占女性总数的34.43 %；男性染色体断裂率为2 的占男性总数的21.72 %，女性染色体断裂率为2 的占女性总数的23.36 %；男性染色体断裂率为3 的占男性总数的7.79 %，女性染色体断裂率为3 的占女性总数的2.87 %；女性染色体断裂率为4 的占女性总数的0.82 %；女性染色体断裂率为6 的占女性总数的0.41 %；女性染色体断裂率为9 的占女性总数的0.41 %。男性患者的染色体断裂率均值无差别（P>0.05）。男、女患者的染色体断裂率均值在1.01，患者平均年龄为29.53 岁，经检查有染色体断裂占64.96 %。通过研究发现，染色体断裂率增高可能是引起夫妇中发生胎停、流产、胎儿发育不良等不良孕产现象的重要原因之一。

关键词： 不育夫妇     不良孕产     染色体断裂率    

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Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristics of Cd and As under joint stress of Cd and As

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

《环境科学与工程前沿（英文）》 2007年 第1卷 第1期   页码 107-113 doi: 10.1007/s11783-007-0020-6

摘要： has been identified as a newly-found Cd-hyperaccumulating species. In the present study, growth responses of and its accumulation characteristics of Cd and As were examined under joint stress of Cd and As. The results showed that Cd and As had an antagonistic effect on enhancing the growth of plants and Cd uptake and accumulation under the low concentration Cd and As treatments. When the concentration of Cd in the soil was 10 mg/kg and the concentration of As was 50 mg/kg, the highest growing height of the plant was up to 35.9 cm and the dry weight of the shoots was up to 2.2 g/pot, respectively. Meanwhile, the accumulation of Cd in the leaves under the joint stress was higher than that at the same level under single Cd pollution. However, there were synergic adverse effects on plant growth and Cd uptake under the combined pollution from a high concentration of Cd and As. Meanwhile, the accumulation of As in the roots was greater than that in the shoots, the translocation factor (TF) was "d0.3 and the bioaccumulation factor (BF) was "d0.6, thus showing that had an excluding effect on As uptake. These results confirmed that had a strong tolerant ability to the joint stress of Cd and As, and the potential for phytoremediation of soils contaminated by Cd and As.

关键词： synergic adverse     stress     present study     potential     weight    

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The cooperation effect of Ni and Pt in the hydrogenation of acetic acid

《化学科学与工程前沿（英文）》 2022年 第16卷 第3期   页码 397-407 doi: 10.1007/s11705-021-2076-4

摘要： The catalytic hydrogenation of carboxylic acid to alcohols is one of the important strategies for the conversion of biomass. Herein, a series of Ni-doped PtSn catalysts were prepared, characterized and studied in the hydrogenation of acetic acid. The Ni dopant has a strong interaction with Pt, which promotes the hydrogen adsorption, providing an activated hydrogen-rich environment for the hydrogenation. Meanwhile, the presence of Ni also improves the Pt dispersion, giving more accessible active sites for hydrogen activation. The cooperation of Pt and Ni significantly promotes the catalytic activity of the hydrogenation of acetic acid to ethanol. As a result, the catalyst with 0.1% Ni exhibits the best reaction activity, and its space time yield is twice as that of the PtSn/SiO2 catalyst. It provides a meaningful instruction on the catalyst design for the carboxylic acid hydrogenation.

关键词： acetic acid     ethanol     hydrogenation     Pt     Ni     cooperation effect    

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标题 作者 时间 类型 操作

design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

期刊论文

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

期刊论文

逆压梯度下近壁湍流的喷射和扫掠

张强,陆利蓬

期刊论文

surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverse

null

期刊论文

浅谈五种宫内节育器不良反应分析

李华洁

期刊论文

基于矿物异常分析的隧道内不良地质识别方法及案例分析

许振浩, 余腾飞, 林鹏, 李术才

期刊论文

Multi-target combinatory strategy to overcome tumor immune escape

期刊论文

Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

null

期刊论文

TBM施工隧洞不良地质超前预报实践——以吉林省中部城市引松供水工程为例

李术才, 聂利超, 刘斌

期刊论文

Analysis of effect of different construction methods of piles on the end effect on skin friction of piles

ZHOU Hongbo, CHEN Zhuchang

期刊论文

A review on different theoretical models of electrocaloric effect for refrigeration

期刊论文

A new miniaturized engine based on thermomagnetic effect of magnetic fluids

Lujun ZHOU, Yimin XUAN, Qiang LI, Wenlei LIAN

期刊论文

244对有不良孕产史夫妇初次染色体断裂率检测结果分析

余宏亮,常明秀,曹恒海,薄立伟,王艳丽,吴艳红

期刊论文

Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristics of Cd and As under joint stress of Cd and As

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

期刊论文

The cooperation effect of Ni and Pt in the hydrogenation of acetic acid

期刊论文